Maqui berry benefits supplement information and review of nutritional benefits Aristotelia chilensis
February 16 2018 by Ray Sahelian, M.D.

Maqui berry is purple colored and found in the Patagonia region of South America. Mapuche Indians consume maqui berries as food as as medicine and have done so for centuries. They report having more strength and stamina. Apparently they use this berry to treat health complaints such as skin inflammation, intestinal disorders, sore throats, and ulcers. Whether this plant is actually helpful for these conditions remains to be evaluated by Western scientists. As of 2016, I found very little published research in humans regarding supplementation.

Claims made and actual benefits
Maqui berries are promoted as having anti-inflammatory, antioxidant, anti-aging, anti-cancer, and natural COX-2 inhibiting activities. It Consumption may also benefit blood sugar control. All edible berries have some health benefit and whether maqui is superior to others remains to be determined.

Overall review of benefits
Curr Pharm Biotechnol. 2016. Bioactive Compounds of Aristotelia chilensis and their Pharmacological Effects. Recently, it has been discovered that the leaves of the maqui berry have important antibacterial and antitumor activities. Anthocyanins, other flavonoids, alkaloids, cinnamic acid derivatives, benzoic acid derivatives, other bioactive molecules, and mineral elements are found in the plant. A broad range of activities of plant extracts and fractions are presented, including antioxidant activity, inhibition of visible light-induced damage of photoreceptor cells, inhibition of α-glucosidase, inhibition of pancreatic lipase, anti-diabetic effects, anti-inflammatory effects, analgesic effects, anti-diabetes, effective prevention of atherosclerosis, promotion of hair growth, anti-photo ageing of the skin, and inhibition of lipid peroxidation.

Q. I read an article in Life Extension magazine on maqui berry and they mentioned many scientific researches on the benefits of maqui berry. What do you think?
   A. Thus far it looks promising but few human studies are available ton confirm many of the benefits predicted from rodent and lab studies.

Antioxidant benefit
J Agric Food Chem. 2010. Antioxidant capacity and in vitro inhibition of adipogenesis and inflammation by phenolic extracts of Vaccinium floribundum and Aristotelia chilensis.

J Am Coll Nutr. 2015. A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin-Maqui Berry Extract (Delphinol ®) on Oxidative Stress Biomarkers. Berries are a rich source of anthocyanins, and clinical data suggest that a polyphenol-rich diet may exert health-promoting effects by reducing oxidative stress. The aim of this study was to elucidate the effects of dietary supplementation with Delphinol (trademark owned by MNL Chile) standardized maqui berry (Aristotelia chilensis) extract on products of lipid peroxidation in healthy, overweight, and smoker subjects. In a double-blind, placebo-controlled design, 42 participants (age 45-65 years) consumed in random order either a standardized extract of maqui berry (162 mg anthocyanins) or a matched placebo, given 3 times daily for 4 weeks. The samples were collected at baseline, after the end of the supplementation, and 40 days after the end of the study. Primary outcome was the measure of oxidized low-density lipoprotein (Ox-LDL) and F2-isoprostanes in plasma and urine, respectively. Secondary outcomes included anthropometric measures, blood pressure, and lipid profile. Delphinol supplementation was associated with reduced levels of Ox-LDL in the anthocyanin group compared to baseline. There was also a decrease in urinary F2-isoprostanes (8-iso-prostaglandin F2α) at 4 weeks versus baseline in the Delphinol-supplemented group. However, no differences in primary outcomes were evident at 40 days of follow-up. In the fourth week of the intervention, no significant differences were noted for anthropometric characteristics, ambulatory blood pressure, and lipid profile. Our observations suggest that dietary interventions with maqui berry extract may improve oxidative status (Ox-LDL and F2-isoprostanes) in healthy adults, overweight adults, and adult smokers.

Blood sugar and diabetes
Biomed Res Int. 2016. Delphinidin-Rich Maqui Berry Extract (Delphinol ®) Lowers Fasting and Postprandial Glycemia and Insulinemia in Prediabetic Individuals during Oral Glucose Tolerance Tests.

Lung health
Nutr J. 2015. The intake of maqui (Aristotelia chilensis) berry extract normalizes H2O2 and IL-6 concentrations in exhaled breath condensate from healthy smokers - an explorative study. Our results suggest that dietary polyphenols might be considered as an interesting alternative for the dietary management of respiratory disorders.

Nutritional content
Maqui berries contain a high concentration of polyphenols and anthocyanins. Some of the specific compounds include anthocyanins, delphinidin, malvidin, petunidin, cumarins, triterpenes, flavonoids, and cyanidin.

Maqui berries [Aristotelia chilensis] have several pigments corresponding to the 3-glucosides, 3,5-diglucosides, 3-sambubiosides of delphinidin and cyanidin. The principal anthocyanin is delphinidin 3-sambubioside-5-glucoside (34% of total anthocyanins). The average total anthocyanin content is 130 mg/100g of fresh fruit. The relative high anthocyanin content and the important presence of polar polyglycosylated derivatives makes the maqui fruits an interesting source of anthocyanin extracts for food and pharmaceutical uses.

J Agric Food Chem. 2010. Polyphenols and antioxidant activity of calafate ( Berberis microphylla ) fruits and other native berries from Southern Chile.
Calafate ( Berberis microphylla ) is a native berry grown in the Patagonian area of Chile and Argentina. In the present study the phenolic composition and antioxidant activity of its fruits were studied and also compared with data obtained for other berry fruits from southern Chile including maqui ( Aristotelia chilensis ) and murtilla ( Ugni molinae ). The anthocyanin content in calafate berries (17.8 micromol g(-1)) and flavonol level (0.16 micromol g(-1)) are comparable with those found in maqui; however, it shows lower flavan-3-ol concentration than calafate (0.11 and 0.24 micromol g(-1), respectively). Maqui and calafate show high antioxidant activity, which correlates highly with total polyphenol content and with anthocyanin concentration.

About the shrub or tree
Maqui (Aristotelia chilensis) is an evergreen shrub or small tree that grows up to 15 feet tall. It is native to the Patagonia region of Chile and Argentina. When Maqui berries are mature, they have an attractive deep purple or black color, usually growing to the size of large blueberries.

Q. I have been hearing that the ORAC value for Maqui berry powder is several times that of Blueberries etc. One website says: Maqui -has the highest ORAC value at approximately 27,600 ORAC units/100g. The Maqui berry’s ORAC values are more than 3x greater than Pomegranate, 5x greater than Blueberry, and 100x greater than redwine." An article in Wilkipedia states that the anthocyanin content of Maqui berries is very low on the scale when compared to many others including blueberry.....the quotaion is: Only limited polyphenol research has been completed on the maqui berry showing its anthocyanin content to include eight glucoside pigments of delphinidin and cyanidin, the principal anthocyanin being delphinidin3-sambubioside-5-glucoside (34% of total anthocyanins). The average total anthocyanin content was 138 mg per 100 g of fresh fruit (212 mg per 100g of dry fruit), ranking maqui low among berries for anthocyanin content  Is this a contradiction, or am I missing something in the data?
   A. I need to see several more studies to determine more accurately the orac value of maqui. In the meantime it is better to have several types of berries in one's diet rather than rely on one or two and to not focus too much on such details.

Products and press releases
These are press releases we have received, the validity of these claims remains to be determined:

Herbal Powers, 2010
The Mapuches Indian has historically consumed maqui berry for a variety of ailments including strength and stamina, blood sugar control, cancer, ulcer and fever. Mapuche warrior drank a fermented beverage made fromit that contribute to their stamina and strength. Maqui Berry fruit has the highest ORAC-H value. In each 100g serving, 27,600 µmole Acai berry has ORAC value of 16,700 µmole, Pomegranate has ORAC value of 10,500 µmole, Blueberry has ORAC value of 6500 µmole. According to Brunswick Laboratories, maqui berry has one of the highest spectrum of antioxidant protection against 5 of the most important free radicals found in human. HPI's maqui berry raw materials has total ORAC over 5000 µmole per gram or 500,000 µmole per 100 gram when tested against all 5 free radicals, making it the highest antioxidant superfruit in the world. Besides high in ORAC value, maqui berry is also high in anthocyanins whose benefits include: to neutralize enzymes that destroy connective tissue, prevent oxidants from damaging connective tissue, repair damaged proteins in the blood-vessel walls, lightens allergic reactions, promote cardiovascular health, prevent oxidation of low-density lipoproteins (LDL), anti-inflammatory, and may have anti-cancer property. Forms we offer:- Maqui berry 65 brix clarified filtered liquid concentrate (Organic)- 17 brix clarified filtered single strength Juice (Organic)- 50 brix Cloudy juice concentrate (Organic).

Brunswick Laboratories has unveiled a new Total ORAC test that measured against 5 of the most important free radicals found in human. Maqui berry has one of the highest spectrums of antioxidant protection against hydroxyl, peroxyl, peroxynitrite, singlet oxygen, and superoxide anion. Among the tested anthocyanins (cyanidin, delphinidin, malvidin, pelargonidin, peonidin and petunidin), delphinidin was the most potent angiogenic inhibitor. Anthocyanins help neutralize enzymes that destroy connective tissue, lightens allergic reactions, promote cardiovascular health, prevent oxidation of low-density lipoproteins (LDL), anti-inflammatory, and may have anti-cancer property. In addition, we also provide custom formulation and private labeling services to the industry.” says Founder and President Annie Eng. About HP Ingredients: HP Ingredients offers more than 200 Standardized Botanical Extracts. When it comes to innovation, HP Ingredients believes in on going research and development for our Proprietary Extracts. We work with scientists from around the world to deliver valuable research. These innovations ensure our customers’ competitiveness and future business growth.

Press release by Novelle International
2008 - Novelle International has launched Maqui Superberry! Maqui Superberry is a high antioxidant fruit known in the world today with an ORAC value probably higher than the average acai, Goji Berry, Noni and Mangosteen products. Maqui Superberry is packed with antioxidants called anthocyanins and contains a high ORAC value. Maqui Superberry, whose ORAC value is certified by Brunswick Laboratories, is power-packed with anthocyanins. Anthocyanins are produced by plants for self-protection against sun, irradiation, diseases and biological enemies; maqui thrives in the harsh climate of central and southern Chile, necessitating the plant’s abundant anthocyanin production. The native Mapuche Indians of the Patagonia region in South America have for centuries benefited from the unique medicinal and healthy aging benefits of the maqui berry. Novelle International Founder and CEO Annie Eng, spent months with the Mapuches researching and working with them to harvest Maqui, then worked with researchers to confirm its antioxidant content. After securing an exclusive distribution agreement in the United States, Annie Eng initiated a socially responsible program that donates supplies and services for the education and healthcare of the Mapuche Indians. Novelle International is proud to give back to a culture that has generously given its health treasure for the American public to enjoy vibrant health.

Maqui Berry fruit has high ORAC-H value. In each 100g serving, value of 27,000 µmole
Acai berry has ORAC-H value of 16,700 µmole
Pomegranate has ORAC-H value of 10,500 µmole
Blueberry has it 6500 µmole

NP Nutra, 2010, press release
This month we are pleased to announce we will be adding a certified organic Maqui freeze-dried Powder, adding to its growing line of high quality Superfruit ingredients. With sales growth of organic products now outpacing conventionally grown foods, the health industry is seeing an unprecedented demand for organically grown ingredients. Andrew Carter, NP Nutra’s Quality Control Manager states, “Inquiries for developing and producing more certified organic ingredients keep coming in from all parts of the food and beverage industry, suggesting that organic products have finally become mainstream. ”Maqui berries have astonishing levels of antioxidants, including anthocyanins, delphinidin, malvidin, petunidin, cumarins, triterpenes, flavonoids, and cyanidin. They are also a good source of vitamin C, calcium, potassium, and iron. Maqui berries are traditionally used to promote strength, endurance, and overall health. The antioxidants in Maqui berries aid normal function of the body's cells, and may help maintain healthy levels of cholesterol and triglycerides. Maqui (Aristotelia chilensis) is an evergreen shrub or small tree that grows up to 15 feet tall and is native to the Patagonia region of Chile and Argentina. When Maqui berries are mature, they are an attractive deep purple or black color, usually growing to the size of large blueberries. “We use the whole maqui berry to maximize the nutritional content of our product while minimizing wastage,” explains Andrew Carter. NP Nutra places a strong emphasis on producing a high quality product in the most sustainable way. By using all three parts of the fruit: the Epicarp (the dark purple/black skin), the Mesocarp (the pulpy meat of the fruit) and the Endocarp (the seeds), the nutritional value of the product is maximized. Tests have shown that the whole berry product has a higher ORAC rating than powder produced from refined Maqui juice. The process of removing seeds results in loss of up to 30-40% of the fruit pulp and/or skin. Andrew Carter comments, “Not only do we maximize ORAC ratings, we are able to produce an ingredient that is far less wasteful and therefore highly sustainable.” NP Nutra manufactures over 100 botanical extracts and ingredients from the most exotic corners of the world. NP Nutra has a complete line of organic and Superfruit ingredients in stock at its Southern California warehouse. Contact NP Nutra for samples and more information on its many organic products.

Where to purchase or buy this product
Buy Maqui berry supplement
Paradise Herbs, Organics, buy Maqui Berry, 60 Veggie Caps
Buy maqui berry 400 mg per capsule