Myeloperoxidase enzyme testing
Peroxidases reduce peroxide through substrate oxidation in order to alleviate oxidative stress in aerobic organisms.
Measuring levels of an enzyme called myeloperoxidase in
the blood may help predict whether apparently healthy individuals are likely to
develop coronary artery disease in the future,
Myeloperoxidase levels tend to be directly related to the likelihood of serious problems in patients with chest pain or suspected coronary disease. Dr. Matthijs Boekholdt, from the Academic Medical Center in Amsterdam, the Netherlands, and colleagues compared initial levels of myeloperoxidase in 1138 healthy subjects who developed coronary disease during 8 years of follow-up and 2237 matched "controls" who did not. People with the highest myeloperoxidase levels had a 36 percent increased risk of coronary disease than those with the lowest levels, the researchers found. In fact, myeloperoxidase levels were useful in predicting coronary disease even when cholesterol levels were normal. Journal of the American College of Cardiology, 2007.
Clin Sci (Lond). 2014. Carbamylation of LDL and its relationship with myeloperoxidase in type 2 diabetes mellitus.