Myricetin is one of the flavonols.
Benefit
Myricetin may have
anti-inflammatory activity. In test tube
studies, it has shown anti-tumor and antioxidant properties. It
may also inhibit beta-amyloid fibril formation, a key problem with
Alzheimer's disease.
Flavonoids have antibacterial and antiviral
activity.
Source Naturals buy Myricetin, 100 mg, 60 Tablets
Myricetin is a naturally occurring flavonoid that is found in berries,
fruits, vegetables, herbs, tea and wine. Many in vitro studies have
demonstrated its antioxidant properties.
Suggested Use: One myricetin tablet a day with a meal, or as recommended
by your health care professional.
Supplement Facts:
Serving Size 1 Tablet
Myricetin 100 mg
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Myricetin research study
Myricetin as the active principle of Abelmoschus moschatus
to lower plasma glucose in streptozotocin-induced diabetic rats.
Planta Med. 2005. Department of Pharmacy, Tajen Institute
of Technology, Yen-Pou, Ping Tung Shien, Taiwan,.
The antihyperglycemic action of myricetin, purified from the aerial part of
Abelmoschus moschatus (Malvaceae), was investigated in streptozotocin-induced
diabetic rats. These results suggest that myricetin has an ability to enhance
glucose utilization to lower plasma glucose in diabetic rats lacking insulin.
Anti-inflammatory health use
Anti-inflammatory Activity of Myricetin Isolated from Myrica rubra Sieb. et Zucc.
Leaves.
Planta Med. 2010.
Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, PR
China.
MYRICA RUBRA leaves are commonly used in folk medicine to treat
inflammatory disorders in China. Present studies on the anti-inflammatory effect
of myricetin from MYRICA RUBRA Sieb leaves was evaluated with various
IN VIVO models of both acute and chronic inflammations such as xylene-induced
ear edema, acetic acid-induced vascular permeability, carrageenan-induced paw
edema, leukocyte migration assay, and cotton pellet granuloma models. Myricetin
showed a significant inhibition on ear edema and hind paw edema caused by xylene
and carrageenan, respectively. Our results also support the claims of
traditional Chinese medicine practitioners about the use of MYRICA RUBRA leaves in the treatment of inflammatory diseases.
Inhibition of interleukin-12 production in mouse
macrophages via decreased nuclear factor-kappaB DNA binding activity by
myricetin, a naturally occurring flavonoid.
Arch Pharm Res. 2005.
Pharmacological inhibition of interleukin-12 (IL-12) production may be a
therapeutic strategy for preventing the development and progression of disease
in experimental models of autoimmunity. In this study, the effects of myricetin,
a naturally occurring flavonoid present in fruits, vegetables and medicinal
herbs, on the production of IL-12 were investigated in mouse macrophages
stimulated with lipopolysaccharide (LPS). Myricetin significantly inhibited the
LPS-induced IL-12 production from both primary macrophages and the RAW264.7
monocytic cell-line in a dose-dependent manner. The effect of myricetin on IL-12
gene promoter activation was analyzed by transfecting RAW264.7 cells with IL-12
gene promoter/luciferase constructs. Furthermore, activation of macrophages by LPS resulted in markedly enhanced
binding activity to the NF-kappaB site, which significantly decreased upon
addition of myricetin, indicating that myricetin inhibited IL-12 production in
LPS-activated macrophages via the down-regulation of NF-kappaB binding activity.
Cancer protection
Life Sci. 2015. Molecular mechanisms underlying anticancer effects of myricetin.
Dietary guidelines published in the past two decades have acknowledged the
beneficial effects of myricetin, an important and common type of herbal
flavonoid, against several human diseases such as inflammation, cardiovascular
pathologies, and cancer. An increasing number of studies have shown the
beneficial effects of myricetin against different types of cancer by modifying
several cancer hallmarks including aberrant cell proliferation, signaling
pathways, apoptosis, angiogenesis, and tumor metastasis. Most importantly,
myricetin interacts with oncoproteins such as protein kinase B (PKB) (Akt), Fyn,
MEK1, and JAK1-STAT3 (Janus kinase-signal transducer and activator of
transcription 3), and it attenuates the neoplastic transformation of cancer
cells.
Dietary flavonoids as proteasome inhibitors and
apoptosis
inducers in human leukemia cells.
Biochem Pharmacol. 2005.
The Prevention Program, Barbara Ann Karmanos Cancer Institute, School of Medicine, Wayne State University,
Detroit, MI
It has been shown that proteasome activity is required for cancer cell survival
and consumption of fruits and vegetables is associated with decreased cancer
risk. In this study, we examined the flavonoids quercetin,
apigenin, myricetin, and kaempferol for their proteasome-inhibitory
and apoptosis-inducing abilities in human tumor cells. We report that apigenin
and quercetin are much more potent than kaempferol and myricetin at: (i)
inhibiting chymotrypsin-like activity of purified 20S proteasome and of 26S
proteasome in intact leukemia Jurkat T cells; (ii) accumulating putative
ubiquitinated forms of two proteasome target proteins, Bax and Inhibitor of
nuclear factor kappabeta-alpha in Jurkat T cells and (iii) inducing activation
of caspase-3 and cleavage of poly(ADP-ribose) polymerase in Jurkat T cells. The
proteasome-inhibitory abilities of these compounds correlated with their
apoptosis-inducing potencies. Results from computational modeling of the
potential interactions of these flavonoids to the chymotrypsin site (beta5
subunit) of the proteasome were consistent with the obtained proteasome-inhibitory
activities. We found that the C(4) carbon may be a site of nucleophilic attack
by the OH group of N-terminal threonine of proteasomal beta5 subunit and that
the C(3) hydroxyl may alter the ability of these flavonoids to inhibit the
proteasome. Finally, apigenin neither effectively inhibited the proteasome
activity nor induced apoptosis in non-transformed human natural killer cells.
Our results suggested that the proteasome may be a target of these dietary
flavonoids in human tumor cells and that inhibition of the proteasome by
flavonoids may be one of the mechanisms responsible for their cancer-preventive
effects.
Myricetin Induces Cell Death of Human Colon Cancer Cells via BAX/BCL2-Dependent Pathway. Anticancer Res. 2014 Feb.
Diabetes
J Med Food. 2013. Effect of emulin on blood glucose in type 2 diabetics.
Emulin is a patented blend of chlorogenic acid, myricetin, and quercetin that
has shown efficacy in reducing midday and post-oral glucose tolerance test (OGTT)
area under the curve (AUC) glucose in streptozotocin-treated rats. This human
trial results suggest that Emulin, if consumed regularly, could not only have
the acute effect of lowering the glycemic impact of foods, but chronically lower
background blood glucose levels of type 2 diabetics.
Estrogenic effect
Toxicol Lett. January 29 2014. The estrogenic effects of apigenin, phloretin
and myricetin based on uterotrophic assay in immature Wistar albino rats.
Chemicals that occur in vegetal food and known as phytoestrogens, because of
their structures similarity to estrogen, have benefits on chronic diseases.
Despite this, when they are taken at high amounts, they can cause harmful
effects on endocrine system of human and animals. In this study, it has been
intended to determine the estrogenic potencies of phytoestrogens apigenin,
phloretin and myricetin whose affinities for estrogen receptors in vitro. The
female rats divided into 17 groups, each containing 6 rats. There was a negative
control group and there were positive control dose groups which contains ethinyl
estradiol, ethinyl estradiol+tamoxifen and genistein. The other dose groups
which were tested for estrogenic activity contains apigenin, myricetin and
phloretin All chemicals have been given to Wistar immature female rats with oral
gavage for 3 consecutive days. By using uterotrophic analysis, uterus wet and
blotted weights, vaginal opening, uterus length of female rats has been recorded
at the end of the experiment. For detect of cell response, luminal epithelium
height, gland number and lactoferrin intensity in luminal epithelium of uterus
were evaluated. Biochemical analysises in blood were performed. Relative uterus
weights of rats in 100mg/kg/day dose group of myricetin were statistically
increased according to vehicle control and positive control groups. In dose
groups of apigenin and phloretin it was found that there were cell responses in
uterus. All treatment groups had a significant difference in the high intensity
of lactoferrin and uterine gland count compared to oil control group. There was
no difference between phloretin and apigenin treatment groups in uterine weight
statictically. Uterine heights were increased in positive control groups and
100mg/kg/day dose group of myricetin. Epithelial cell heights were increased in
treatment groups except apigenin and phloretin dose groups. There was no
difference between all treatment groups in vaginal opening values according to
positive control.
Sleep influence
Biochem Biophys Res Commun. 2013 Oct 18. The flavonoid myricetin reduces
nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase.
Preformed beta-amyloid fibrils are destabilized by
coenzyme Q10 in vitro.
Biochem Biophys Res Commun. 2005.
Inhibition of the formation of beta-amyloid fibrils (fAbeta), as well as the
destabilization of preformed fAbeta in the CNS, would be attractive therapeutic
targets for the treatment of Alzheimer's disease. We reported previously that
nordihydroguaiaretic acid (NDGA) and wine-related polyphenol, myricetin, inhibit
fAbeta formation from Abeta and destabilize preformed fAbeta in vitro. Using
fluorescence spectroscopic analysis with thioflavin T and electron microscopic
studies, we examined the effects of coenzyme Q10 (CoQ(10)) on the formation,
extension, and destabilization of fAbeta at pH 7.5 at 37 degrees C in vitro. We
next compared the anti-amyloidogenic activities of CoQ10 with NDGA and myricetin.
Coenzyme Q10 dose-dependently inhibited fAbeta formation from amyloid
beta-peptide (Abeta), as well as their extension. Moreover, it destabilized
preformed fAbetas. The anti-amyloidogenic effects of Coenzyme Q10 were slightly
weaker than those of NDGA and myricetin. Coenzyme Q10 could be a key molecule
for the development of therapeutics for Alzheimer's disease.
Anthocyanins, flavonols, and free radical scavenging
activity of Chinese bayberry (Myrica rubra) extracts and their color properties
and stability.
J Agric Food Chem. 2005.
Characterization of anthocyanins and flavonols and radical scavenging
activity assays of extracts from four Chinese bayberry (Myrica rubra) varieties
with different fruit colors were carried out. One dominant anthocyanin and three
major flavonols were isolated by HPLC, and cyanidin-3-O-glucoside and two of
three flavonols, myricetin and quercetin-3-O-rutinoside, were identified by
cochromatography with authentic standards. Both DPPH* and ABTS*(+) cation assays
indicated that the black varieties (Biji and Hunan) demonstrated much higher
radical scavenging activities than the pink (Fenhong) and yellow (Shuijing)
varieties, which may be attributed to much higher levels of anthocyanins,
flavonoids, and total phenolics in the black varieties.
Myricetin inhibits matrix metalloproteinase 2 protein
expression and enzyme activity in colorectal carcinoma cells.
Mol Cancer Ther. 2005.
Because the activation of matrix metalloproteinases (MMP) is
a key factor in the metastatic process of colon cancer, agents with the ability to inhibit MMP
activity have potential in the treatment of colorectal carcinoma. In the present
study, among 36 flavonoids examined, myricetin was found to be the most potent
inhibitor of MMP-2 enzyme activity in COLO 205 cells. Results of the present study indicate that myricetin significantly blocked both
endogenous and TPA-induced MMP-2 enzyme activity by inhibiting its protein
expression and enzyme activity. The blockade involved suppression of PKC
translocation, ERK phosphorylation, and c-Jun protein expression.
Cactus Botanics introduces
Myricetin extracted from Bayberry Bark
Myricetin is a flavonoid that is commonly found in natural food sources such as
berries, vegetables, teas, wine and herbs. Myricetin is considered to be an
antioxidant, which means that it is capable of eliminating free radicals within
the body. It is usually taken from the bark, leaves, and roots of the plant
known as myrica cerifera, and is completely water soluble, which means it makes
an excellent source for teas. Cactus Botanics introduces Myricetin 80%, tested
by HPLC.