Norepinephrine neurotransmitter increase
August 17 2017

Norepinephrine or noradrenaline is a hormone and a neurotransmitter; it is secreted by the adrenal medulla as a hormone into the blood, and as a neurotransmitter from neurons. Along with epinephrine (adrenaline), another hormone secreted by the adrenal medulla, norepinephrine is involved in the fight-or-flight response to physical or mental stress, directly increasing heart rate, triggering the release of glucose from energy stores, and increasing skeletal muscle readiness, among other actions.

Brazilian J Med Biol Research. 2014. Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells.

Clin Exp Obstet Gynecol. 2015. Methamphetamine, smoking, and gestational hypertension affect norepinephrine levels in umbilical cord tissues. These studies were undertaken to determine methamphetamine (METH) and smoking effects on umbilical vascular dynamics and pregnancy outcomes. Umbilical cords (54) were collected prospectively at birth, washed of blood, and stored at -80C. Cords were thawed and lysates prepared, then catecholamine levels quantified with enzyme-linked immunosorbent assay (ELISA). Catecholamine levels in umbilical cords were not associated with maternal or gestational age, gravidity, parity, neonatal or placental weight. Neither smoking nor METH affected dopamine or epinephrine. However, smoking (two-fold) and METH (four-fold) decreased norepinephrine and together a 60-fold reduction occurred. Cesarean section and hypertension were both associated with lower norepinephrine levels regardless of drug status. In normotensive pregnancies, smoking and METH significantly decreased norepinephrine levels (two-fold and 3.5-fold each, respectively) with a 40-fold decrease for METH/smoking together. Depletion of norephinephrine by METH and smoking likely contributes to pregnancy complications, including the higher incidence of respiratory distress and postpartum hemorrhage in cesarean section.

Q. I have read information you have posted on the Internet for the last few years and have found it extremely useful. I have a question that no person, physician or company has an answer too. Is there a supplement or medication that raises the norepinephrine levels in the body without the use of central nervous system stimulants? Stimulants prescribed by a physician, and over the counter supplements only last for a few days. Medications effecting other neurotransmitters (i.e. seretonin) at the same time as effecting norepinephrine makes them counter productive. If there is any way to raise norepinephrine levels by itself, I am sure this will help my energy level.
   A. I am aware of the amino acid tyrosine leading to an elevation of norepinephrine and the amino acid phenylalanine. Energy levels in the body are influenced by a host of factors, not just the levels of one substance. As such, I don't see the need to focus on one neurotransmitter levels. One should rather focus on a number of natural ways to improve energy.

J Am Heart Assoc. 2013. Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome.