Norvaline amino acid benefit
August 17 2017 by
Ray Sahelian, M.D.


L-Norvaline is an analog of the branched chain amino acid Valine. It has been proposed that L-Norvaline inhibits the arginase enzyme thus increasing arginine concentrations. Arginine is known to convert into nitric oxide. As of 2017, human studies with norvaline supplements are not available and hence no confident claims can be made regarding the benefit or side effect of norvaline supplementation.


BMC Cardiovasc Disord. 2009. Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. Pharmacological inhibition of endothelial arginase-II has been shown to improve endothelial nitric oxide synthase (eNOS) function and reduce atherogenesis in animal models. We investigated whether the endothelial arginase II is involved in inflammatory responses in endothelial cells. The arginase inhibitor L-norvaline exhibits anti-inflammatory effects independently of inhibition of arginase in human endothelial cells. The anti-inflammatory properties of L-norvaline are partially attributable to its ability to inhibit S6K1.


L-Norvaline Methyl Ester HCL

and Ethyl Ester HCL

Produced by: Actinomycetes


I just wanted to write you regarding this product L-Norvaline, which I came across mentioned on your website. I purchased it recently in my efforts to deal with effects of chronic, untreated Lyme Disease. Looking up the topic of arginase before purchasing this product, I was really excited. Because some of my earliest symptoms involved sensations of ear pressure changes that might be explained by this arginase enzyme causing interference with production of regular arginine / nitric oxide supplies. I also thought this might be connected with the stimulation of the anaerobic stress system by the bacteria or its pathogenic effects. So I tried it, hoping for the best. Well, it is wonderful. Due to the energy channel-opening effects of 7-years intensive martial arts practice, my case of Lyme is so bad that I can literally feel abdominal sensations when the anaerobic metabolism is being triggered by the Lyme for its feeding. Take one of these L-Norvaline pills seems to stop that changeover. My hope is that by preventing arginase triggering, the bacteria cannot feed itself and thus will die off over time. Of course there's the seedpod state that can remain in one's system, like cancer, without food, but these must also get stimulated from time to time into active forms that can be addressed in this same way. Happily, this product has also improved the symptoms of the ear pressure changes. My health in general seems to be normalizing and my immune system rebounding in a wonderful way. The only concern I have is that it might actually normalize too much, as the bacteria spread is so pervasive and its effects so immuno-depressive, that to eliminate too much of the bacteria too quickly seems to risk overwhelming one's body's abilities to repair corrupted / sickened areas.