Availability, where to buy
You can find Pau D'arco in tablet or capsule form, as tea, and
combined with other nutrients and herbs in many formulas. It is sold in
health food stores and online.
What's in the herb?
Some of the beneficial chemicals in this plant are lapachol, glycosides, quercetin, and other flavonoids.
Beta-lapachone is found in Pau
D'arco
Beta-Lapachone is a novel anticancer agent with selectivity
against prostate cancer and possibly retinoblastoma and other cancers. Beta
lapachone is being studied either by itself or in combination with chemotherapy
drugs as a treatment for various types of cancer.
Benefits
In some studies, the active phytochemicals in Pau d'Arco have been found to show
strong in vitro activity against bacteria, fungi, and yeast. Pau d'Arco's may
support the immune system.
Pau D'arco has antioxidant properties at a
power similar to vitamin E.
Antioxidant activity and characterization of volatile constituents of Taheebo (Tabebuia
impetiginosa)
J Agric Food Chem 2003.
Volatiles were isolated from the dried inner bark of Tabebuia impetiginosa. The major volatile constituents of pau darco were
4-methoxybenzaldehyde, 4-methoxyphenol, 5-allyl-1,2,3-trimethoxybenzene (elemicin), propenylbenzene (trans-anethole),
and 4-methoxybenzyl alcohol. The antioxidant activity of the volatiles was
evaluated using two different assays. The extract exhibited a potent inhibitory effect on
the formation of conjugated diene hydroperoxides (from methyl linoleate). The extract also inhibited the oxidation of hexanal for
40 days at a level of 5 microg/mL. The antioxidative activity of
pau darco
volatiles was comparable with that of the well-known antioxidants, alpha-tocopherol, and
butylated hydroxytoluene.
Hyperpigmentation
Arch Dermatol Research. 2015. Melanogenesis inhibition of β-lapachone, a natural product from Tabebuia
avellanedae, with effective in vivo lightening potency. β-Lapachone is
an ortho naphthoquinone obtained from the bark of the lapacho tree (Tabebuia
avellanedae), which has been used medicinally for centuries. The purpose
of this study was to investigate the effects of β-lapachone on
inhibitory mechanism of melanogenesis. β-Lapachone inhibited melanin
synthesis and tyrosinase activity at 0.8 μM in melan-a cells. Also, β-lapachone
reduced the expression of tyrosinase and tyrosinase-related protein-1 at
transcriptional and translational levels. The decreased expression of
tyrosinase and tyrosinase-related protein-1 might result from the
reduced microphthalmia-associated transcription factor (MITF) level
which regulates major melanogenic proteins. The reduced level of MITF
was associated with delayed ERK activation by β-lapachone. Furthermore,
β-lapachone reduced melanogenesis in the human 3D skin tissue culture;
besides, it dramatically inhibited body pigmentation of zebrafish and
decreased melanin content and tyrosinase activity. These results show
that β-lapachone may be useful as a potential depigmentation agent for
various hyperpigmentation disorders.
Research
studies
Constituents from the bark of Tabebuia impetiginosa.
Phytochemistry. 2004.
The bark of pau darco afforded nineteen glycosides,
consisting of four iridoid glycosides, two lignan glycosides, two
isocoumarin glycosides, three phenylethanoid glycosides and eight phenolic
glycosides. Iridoid glycosides, phenylethanoid glycosides and lignan
glycosides had ajugol, osmanthuside H and secoisolariciresinol
4-O-beta-D-glucopyranoside as their structural elements, respectively,
whereas the aglycone moieties of the isocoumarin glycosides were
considered to be hydroxymellein. Phenolic glycosides had
4-methoxyphenol, 2,4-dimethoxyphenol, 3,4-dimethoxyphenol,
trimethoxyphenol and vanillyl 4-hydroxybenzoate as each aglycone
moiety. Additionally, the sugar chains of these isocoumarin glycosides and
phenolic glycosides were concluded to be beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside
as well as those of osmanthuside H and above phenylethanoid glycosides.
J Ethnopharmacol. 2009. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity?. Red Lapacho (Tabebuia impetiginosa, syn. Tabebuia avellanedae), a canopy tree indigenous to the Amazonian rainforest and other parts of South America, has been acclaimed to be one of the "miraculous" cures for cancer and tumours. For the first time, during the 1960s, it attracted considerable attention in Brazil and Argentina as a 'wonder drug'. Traditionally, the botanical drug is widely used in local and traditional phytomedicine, usually ingested as a decoction prepared from the inner bark of the tree to treat numerous conditions like bacterial and fungal infections, fever, syphilis, malaria, trypanosomiasis, as well as stomach and bladder disorders.
Different species
Tabebuia altissima
Tabebuia avellanedae.
β-Lapachone is a natural compound extracted from the bark of the lapacho
tree.
Molecules. 2013. Bioactive Phenylpropanoid Glycosides from Tabebuia
avellanedae.
J Ethnopharmacol. 2013. Antidepressant-like action of the bark
ethanolic extract from Tabebuia avellanedae in the olfactory
bulbectomized mice.
Phytother Res. 2013. Antiulcer Effect of Bark Extract of Tabebuia
avellanedae: Activation of Cell Proliferation in Gastric Mucosa During
the Healing Process.
Tabebuia impetiginosa
Chem Pharm Bull (Tokyo). 2013. Synthesis and cytotoxicity on human leukemia cells of furonaphthoquinones isolated from tabebuia plants.
Inquiries
Does this herb provide any
sexual enhancement?
Not that I am aware of,
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Nature's Way, Pau d'Arco Inner Bark, 545 mg, 180 Veggie Caps
buy Pau D'Arco supplement
Pau D' Arco (Tabebuia altissima) is the highest quality inner bark of the
Purple Lapacho tree found in Brazil and Northern Argentina. Ever since
ancient times, when it was a standard for the medicine men of the Inca
Empire, pau d'arco (also known as ipe roxo and taheebo) has been one of
the most widely used herbs in South America. Its popularity is attributed
to the active constituents, lapachol and beta-lapachone, which have been the subject of
numerous scientific studies.
Buy Pau D'arco herbal supplement
| Serving Size: 2 Capsules | ||
| Serving Per Container: 90 | ||
| Amount Per Serving | %DV | |
| Total Carbohydrate | <1 g | <1%† |
| Pau d'Arco (inner bark) | 1.09 g | ** |
| †Percent Daily Values (DV) are based on a 2,000 calorie
diet. **Daily Value not established. |
||
Supplement Facts:
Pau D'Arco bark (Tabebuia altissima)
Buy Pau Darco bark,
Purchase Pau Darco bark supplement