Piracetam, a derivative of the neurotransmitter gamma-aminobutyric acid (GABA),
has a variety of physiological effects that may result, at least in part, from
the restoration of cell membrane fluidity. At a neuronal level, piracetam
modulates neurotransmission in a range of transmitter systems (including
cholinergic and glutamatergic), has neuroprotective and anticonvulsant
properties, and improves neuroplasticity. At a vascular level, it appears to
reduce erythrocyte adhesion to vascular endothelium, hinder vasospasm, and
facilitate microcirculation. Piracetam is sold under a wide variety of brand
names around the world, in Europe it is sold as Nootropil and Lucetam
In rodent studies, the piracetam like nootropics are capable of
achieving reversal of amnesia induced by, e.g., scopolamine, electroconvulsive
shock and hypoxia.
In the United States, it is not approved by the US Food and Drug Administration for any medical use and it is not permitted to be sold as a dietary supplement.
Medical and mental enhancement uses
Piracetam is used in cognitive disorders and dementia,
vertigo, cortical myoclonus,
dyslexia, and sickle cell anemia. Piracetam has neuroprotective and
antithrombotic effects which may help to reduce death and disability in people
with acute stroke, however there is still no proof that it is effective
for this purpose.
Many people use piracetam as a nootropic supplement or mind booster.
Additional nootropic articles and
information
Aniracetam nootropic
beenfit
Oxiracetam nootropic
research
Is
Pyrrinol superior or better than piracetam?
I have not seen comparison studies to know and I have not tried
either one yet.
Piracetam and Cognition, mental effects
Piracetam prevents cognitive decline in coronary artery bypass: a randomized
trial versus placebo.
Ann Thorac Surg. 2006. Department of Neurology, University
of Targu-Mures, Targu Mures, Romania.
Coronary artery bypass grafting (CABG) can be associated with
postoperative cognitive impairment and ischemic stroke. The aim of this study
was to evaluate the effectiveness of piracetam to treat the cognitive impairment
after CABG in an investigator-initiated, double-blind, placebo-controlled,
randomized clinical trial. Patients undergoing CABG (n = 98) were
randomized to placebo or piracetam. Study drugs were
administered intravenously (150 mg/kg daily; 300 mg/kg on the day of surgery)
from the day before surgery to 6 days after surgery, then orally (12 g/day) up
to 6 weeks after surgery. Six weeks after CABG, cognition was
significantly improved in patients treated with piracetam.
Exp Ther Med. Feb 2014 Feb. Effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery: A meta-analysis. Cognitive impairments are observed in numerous patients following coronary bypass surgery, and piracetam are nootropic compounds that modulate cerebral functions by directly enhancing cognitive processes. The present meta-analysis was conducted to evaluate the protective effect of piracetam on the cognitive performance of patients undergoing coronary bypass surgery. The relevant studies were identified by searching Medline, EMBASE, PubMed and the Cochrane Library up to June 2013 and the pertinent bibliographies from the retrieved studies were reviewed. Results indicated that piracetam may have been effective in improving the short-term cognitive performance of patients undergoing coronary bypass surgery.
Emails
Q. Does your research group have more information about
Picamilon and Piracetam?
Do you think they will enhance cognition?
A. It appears that piracetam does have a role to play in cognition.
Q. Do you have any opinion on piracetam? Are you
planning to do more reviews of other nootropics any time soon?
A. I have focused mostly on natural herbs and nutrients as mind
enhancers, and not as much on piracetam or other nootropics. I personally have
not taken a piracetam pill.
I was wondering what Dr. Sahelian's opinions on
Pyritinol and Piracetam are, if he has any. In the case of Pyritinol, in
particular I was wondering his opinion on whether or not it should be seen as an
"as needed" sort of item or if long term use is generally safe with it.
I prefer to take these brain boosters on an as needed basis
as opposed to regularly. Long term side effects of daily use are not fully
understood.
I am 33 years old and looking for cognitive support. I
had Glandular Fever last and haven't worked for a year. I feel like, I have lost
interest, not very motivated, don't think as fast and memory not as good as it
it use to be. I think its a combination of having glandular fever and being at
home. But I feel better after taking herbs glands are back to normal, don't feel
fatigued and tired all the time. I have experiemented with nootropics and find
these 3 help with what I lack at the moment. I would like to know if I can take
these 3 daily are they safe? Centrophenoxine 250 mg, Oxiracetam 800mg and
Huperzine A 50mcg?
Long term safety of either alone has not yet been established, let
alone taking them together. One option is to use the lowest effective dosage and
to try to occasionally to take breaks or substitute other brain enhancers.
Testimonial
I cherish the extreme relief effect that I feel
piracetam brings to my nervous system.