Platycodon root
February 1 2017

Platycodon grandiflorum has a long history of use as a traditional herbal medicine for the treatments of cough, phlegm, sore throat, lung abscess, chest pain, dysuria, and dysentery. As a legal medicine and dietary supplement, it is also frequently used as an ingredient in health foods and vegetable dishes.

As of 2016, we have not seen any human studies with this substance.

The roots of Platycodon grandiflorum, which belongs to the Campanulaceae family, have been used as a food material and as a traditional Oriental medicine. Platycodon grandiflorum is used as a traditional oriental medicine and also as a food in Korea.

Platycodon grandiflorum herb information and research studies
Platycodon grandiflorum has several compounds including tangeritin, 3-O-beta-D-glucopyranosylplatycodigenin methyl ester, 3-O-beta-D-glucopyranosylplaticogenic acid A lactone, 3-O-beta-D-glucopyranosylplatycodigenin, deapio-platyconic acid A lactone, deapio-platycodin-D, platycoside-G1 and platycoside-E.

Evid Based Complement Alternat Med. 2013. Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication. Triterpenoid saponins, platycoside F, platycoside B, and platycoside C.

Environ Toxicol Pharmacol. 2013. Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines.

Isolation of a new saponin and cytotoxic effect of saponins from the root of Platycodon grandiflorum on human tumor cell lines.
Planta Med. 2005. Korea Research Institute of Chemical Technology, Taejeon, Korea.
A novel triterpenoid saponin, deapioplatycoside E (1) was isolated from the root extract of Platycodon grandiflorum, together with the seven known saponins 2 - 8, i. e., platycoside E (2), deapioplatycodin D3, platycodin D3 (4), polygalacin D2 (5), platycodin D2 (6), deapioplatycodin D (7) and platycodin D. The crude saponin fraction and compounds 6 - 8 exhibited significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro.

Platycodon grandiflorum protects liver tissue
Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice.
Food Chem Toxicol. 2009, College of Pharmacy, Chosun University,, Gwangju, Republic of Korea.
The protective effects of saponins isolated from the root of Platycodon grandiflorum (Changkil saponins: CKS) against alcoholic steatosis in liver injury induced by acute ethanol administration were investigated. Our findings suggest that Platycodon grandiflorum saponins may prevent ethanol-induced acute liver injury, possibly through its ability to block CYP2El-mediated ethanol bioactivation and its free radical scavenging effects.