Raspberry Ketone used for weight loss and promoted as a miracle
February 10 2016
Q. I heard about Dr. Oz recommending raspberry ketones for
increasing adiponectin for weight loss. He is even saying it makes a person
moreinsulin sensitive I think. Is this another flash in the pan?
A. This is a new supplement on the market and I would like to see more research before making any recommendations.
Sci Rep. 2014. Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis.
J Med Food. 2014. Raspberry Ketone Promotes the Differentiation of C3H10T1/2 Stem Cells into Osteoblasts.
J Med Food. 2012. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis.
Planta Med. 2010.
Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes.Park KS. Nutrition & Functional Food Research Team, Korea Food & Drug Administration, Seoul, Korea.
Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration of RK to male mice has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes. To elucidate a possible mechanism for the antiobesity action of RK, its effects on the expression and the secretion of adiponectin, lipolysis, and fatty acid oxidation in 3T3-L1 were investigated. Treatment with 10 ÁM of RK increased lipolysis significantly in differentiated 3T3-L1 cells. An immunoassay showed that RK increased both the expression and the secretion of adiponectin, an adipocytokine mainly expressed and secreted by adipose tissue. In addition, treatment with 10 ÁM of RK increased the fatty acid oxidation and suppressed lipid accumulation in 3T3-L1 adipocytes. These findings suggest that RK holds great promise as an herbal medicine since its biological activities alter the lipid metabolism in 3T3-L1 adipocytes.
Food Funct. 2014. Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis. Berries are an important dietary source of fibres, vitamins, minerals and some biologically active non-nutrients. A red raspberry fruit extract was characterized in terms of phenolic content and the anti-inflammatory properties and protective effects were evaluated in two experimental models of inflammation. The antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils' oxidative burst were also studied to provide a mechanistic insight for the anti-inflammatory effects observed. The extract was administered in a dose of 15 mg kg(-1), i.p. and significantly inhibited paw oedema formation in the rat. The same dose was administered via i.p. and p.o. routes in the collagen-induced arthritis model in the rat. The extract showed pharmacological activity and was able to significantly reduce the development of clinical signs of arthritis and markedly reduce the degree of bone resorption, soft tissue swelling and osteophyte formation, preventing articular destruction in treated animals.