Extracts from the fruits (seeds) of Schisandra chinensis are one of the components of medicinal preparations designed for the treatment of cardiovascular diseases, liver diseases, diseases of the central nervous system related to the old age, as a supplement in the treatment of neoplasms, diabetes, etc. Schisandra extracts are also used for the production of nutraceuticals (soft drinks and health foods), preparations for oral hygiene and for the care for the skin and hair. See Chinese Herbs of list of herbs used in Chinese Medicine.
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Suggested Use: 1 capsule daily or as directed by a qualified healthcare
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About the herb
J Nat Prod. 2013. Bioactive dibenzocyclooctadiene lignans from the stems of
Schisandra neglecta. Seven new unusual dibenzocyclooctadiene lignans, neglignans
A-G (1-7), together with 16 known dibenzocyclooctadiene lignans, were isolated
from the stems of Schisandra neglecta.
Properties and benefits
Diabetic nephropathy
J Tradit Chin Med. 2012. Inhibition mechanism of compound ethanol extracts from
wuweizi (fructus schisandrae chinensis) on renal interstitial fibrosis in
diabetic nephropathy model mice. Department of Nephrology, Tianjin Public
Security Hospital, Tianjin, China. To evaluate inhibition effect and mechanism
of compound ethanol extracts from Wuweizi (Fructus Schisandrae Chinensis),
Chuanxiong (Rhizoma Chuanxiong) and Muli (Cocha Ostreae) (FRC) on glomerular and
tubular interstitial fibrosis in streptozocin (STZ)-induced diabetic nephropathy
(ND) model mice. FRC can ameliorate the DN in the C57BL/6 mice, and its
mechanism may relate to inhibition on the epithelial to mesenchymal
transdifferentiation, endothelial-myofibroblast transition and PAL-1 expression.
Heart health
Prostate enlargement benefit
Sleep and insomnia
Schisandra Research
studies
Eur J Pharmacol. 2014. Pharmacological evaluation of sedative and hypnotic
effects of schizandrin through the modification of pentobarbital-induced sleep
behaviors in mice. The fruits of Schisandra chinensis have been recorded as an
effective somnificant for the treatment of insomnia in some oriental countries
pharmacopoeias. However, the mechanism of sedative and hypnotic effects of this
kind of herb is still unclear. In the present study, schizandrin, which is the
main component of Schisandra chinensis, was selected as a target compound to
investigate possible mechanisms through behavioral pharmacology methods. The
results showed that schizandrin possessed dose-dependent (5-45mg/kg, i.p.)
sedative effects on locomotion activity in normal mice, and produced a
dose-dependent decrease in sleep latency and an increase in sleep duration in
pentobarbital-treated mice; thus, itself did not induce sleep at higher dose
which was used in this experiment (45mg/kg, i.p.). It also can reverse the
rodent models of insomnia induced by p-chlorophenylalanine (PCPA) and caffeine,
which could exhibit a synewith 5-hydroxytryptophan (5-HTP) as well; therefore,
the hypnotic effects of schizandrin were not inhibited by flumazenil (a specific
gamma aminobutyric acid (GABA)-A-BZD receptor antagonist). Altogether, these
results indicated that schizandrin produces beneficial sedative and hypnotic
bioactivity, which might be mediated by the modification of the serotonergic
system. Schisandra supplement emails I would like to know if
schizandra herb has potential to
cause one's immune system to attack the thyroid to a greater degree in those
with Hashimoto's, as I would like to try it. Also it is stated that schixandra
can irreversibly inhibit CYP3A4. Is that a permanent effect? I ask this because
I do take diazepam, and it is broken down by that particular isoenzyme. I do
know that schixandra inhibits CYP3A4 but can't imagine it being permanent. Could
you clarify please? Your answers to my questions will be taken as your opinion
and nothing else. I fully understand that there are no definitive answers yet,
and that everyone's physiology is different and will experience different
results. Does it interfere with
5-htp for mood balance
and better appetite control? Q. I have been visiting your site and I
really like the information! Since I am from Norway, my english is not perfect
:) I was reading your article about Schisandrae and I came across a study where
Schisandrae was compared to Oxymetholone (anadrol 50. Worlds strongest oral
anabolic steroid). Ffructus schisandra inhibits muscle atrophy almost as well as
oxymetholone. They used ethanol extract. Do you know where to find ethanol
extract? Other Products online Buy Schisandra supplement Supplement Facts,
Amount Per Serving: Schisandra
extract 9% Schisandrins
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Schisandra chinensis is an aromatic, woody vine that is native to
northern and northeastern China . It is fully ripened in the fall
and appears as numerous spikes of tiny, bright red berries. The berries have
sweet, sour, hot, salty, and bitter tastes -- hence the Chinese name for schisandra, "Wu Wei Zi" (five-flavored herb).
Schisandra chinensis, originally a Japanese-Manchurian endemite, yields a
vegetable drug (Schisandrae fructus) with a number of very utilizable therapeutic effects.
Studies indicate it has liver protective, adaptogenic, and antioxidative
capabilities. It is obvious that a very positive therapeutic effect based on the use of a
complex mixture of schisandra's principal constituents because their biological effects are
complementary and potentiate each other. At the same time, some lignans (e.g. gomisin A,
gomisin N) are interesting as new prospective medicines.
Components of schisandra, what's in it?
Some of the active ingredients in schisandra include
dibenzocyclooctadiene lignans, schizandrin, wuweizisu A, B, C;wuweizichun
A, B; wuweizi ester and schisanhenol. A variety of active constituents including
acids, phytosterols (beta-sitosterol and stigmasterol), ivtamins C and E,
volatile oils and at least 30 different lignans (deoxyschizandrin, gomisins,
pregomisin, schizandrin, and others), have been isolated from schisandra.
Antioxidant and liver protection
Schisandrin B (Sch B), an active
ingredient of the fruit of Schisandra chinensis, enhances the hepatic
glutathione
antioxidant system in mice, as evidenced by the hepatoprotection against carbon
tetrachloride (CCl4) toxicity. The mechanism of hepatoprotection afforded by Sch B treatment may involve the enhancement of mitochondrial
glutathione redox status.
J Ethnopharmacol. 2012. Schisandra chinensis fruit extract attenuates
albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced
diabetic nephropathy.
Our studies suggest that SE might be beneficial for diabetic nephropathy. The
effects of SE on attenuating albuminuria and glomerulosclerosis are possibly
mediated by preserving podocyte integrity through suppressing epithelial-to-mesenchymal
transition.
Fitoterapia. 2014. The protective effects of Schisandra chinensis fruit
extract and its lignans against cardiovascular disease: a review of the
molecular mechanisms. Schisandra chinensis fruit extract has traditionally been
used as an oriental medicine for the treatment of various human diseases,
including cardiovascular disease. To date, emerging experimental evidence
supports the therapeutic effects of the Schisandra or its bioactive lignan
ingredients in cardiovascular disease, unraveling the mechanistic basis for
their pharmacological actions.
Protection of brain cells
Dibenzocyclooctadiene lignans from Schisandra
chinensis may possess therapeutic potential against oxidative neuronal damage
induced by excitotoxins.
J Ethnopharmacol. 2014. Effects of Schisandra chinensis extract on the
relaxation of isolated human prostate tissue and smooth muscle cell. Schisandra
chinensis has been commonly used as a traditional herbal medicine to treat
various diseases including body weakness, dysentery, impotence, enuresis and
frequent urination in many countries including Korea, China and Russia. Benign
prostate hyperplasia is a common disease for the elderly men and it induces
lower urinary tract symptoms which hinder general activity and quality of life.
We evaluated the therapeutic potential of Schisandra chinensis extract in benign
prostate hyperplasia using human prostate tissue. Schisandra extract showed a
dose dependent relaxation effect on human prostate tissue as well as an additive
effect with tamsulosin.
J Food Drug Anal. 2016. Sedative and hypnotic effects of supercritical carbon
dioxide fluid extraction from Schisandra chinensis in mice. This study was
conducted to investigate the sedative and hypnotic activities of the
supercritical carbon dioxide fluid extraction of S. chinensis in mice and the
possible mechanisms. Schisandra exhibited an obvious sedative effect on
shortening the locomotor activity in mice in a dose-dependent manner. The herbal
extract showed a strong hypnotic effect in synergy with pentobarbital in mouse
sleep, and reversal of insomnia induced by caffeine, p-chlorophenylalanine and
flumazenil by decreasing sleep latency, sleep recovery, and increasing sleeping
time. In addition, it produced a synergistic effect with 5-hydroxytryptophan
(2.5 mg/kg, intraperitoneally). The behavioral pharmacological results suggest
that this herb has significant sedative and hypnotic activities, and the
mechanisms might be relevant to the serotonergic and γ-aminobutyric acid (GABA)
ergic system.
Identification and Characterization of Potent CYP3A4
Inhibitors in Schisandra Fruit Extract.
Drug Metab Dispos. 2004.
Schisandra fruit is used as a component in Kampo
medicines (developed from Chinese medicines, but established in Japan). It can
act as a sedative and antitussive, improve hepatic function, and give a general
tonic effect. An extract of Schisandra fruit has been shown with a potent
inhibitory effect on human liver microsomal erythromycin N-demethylation
activity mediated by cytochrome P450 3A4 (CYP3A4). The present study was
conducted to identify Schisandra fruit components having inhibitory effects on
CYP3A4 by surveying the effect on human liver microsomal erythromycin N-demethylation
activity. Known components of Schisandra fruit, gomisins B, C, G, and N and
gamma-shizandrin, showed inhibitory effects on N-demethylation activity. Among
these components, gomisin C displayed the most potent and competitive inhibitory
effect. These results indicate that gomisin C is a mechanism-based inhibitor
that not only competitively inhibits but irreversibly inactivates CYP3A4.
I am researching taking schisandra, and see that it increases
estrogen
receptivity. This sounds like something to be avoided if one has had type
breast cancer; whether or not cells were found to be estrogen-receptive. Yet, I
see no warnings in the literature.
It's really difficult to make any firm statements
regarding the long term effect of an
herb on the human body based on a
laboratory study of what an herb does to specific cells to what it would
do in humans after digestions, absorption, and modification. Herbs
considered Phytoestrogens may have some estrogen-like activity, but in a
subtle and usually non-harmful, non tumor-stimulating way.
I don't think it is a permanent effect. Thyroid schisandra
search on Medline did not reveal any studies regarding the influence of the herb
on the thyroid gland.
I am not sure yet.
A. You may have to email specific companies to find out, I have not
looked into the different products on the market to see which ones use alcohol
extract.
buy Schisandra Extract, 250 mg
Schisandra is naturally extracted using only the
finest quality Fructus Schisandra chinesis. Our standardized extract provides active levels of schisandrins, concentrated in
the balanced ratio nature intended, without isolating, fractionizing or
using toxic solvents, harsh chemicals or gases.
Schisandra is a famous tonic traditionally used by both royalty and master
herbalists. It is one of the few herbs that contain the three treasures
known as Jing, Qi and Shen. Traditionally used for enhancing the energy of
the kidney and liver, Schisandra is known for supporting memory and sexual
endurance. It is mildly calming and helps strengthen the primary energies
of life. As a tonic it supports overall vitality.*
Supplement Facts Schisandra extract
Serving Size: 1 Vegetarian Capsule
Amount Per Vegetarian Capsule
% Daily Value
Schisandra chinensis fruit extract 10:1
Wu Wei Zi250 mg
*
*Daily Value not established.
Schisandra chinesis fruit four to 1 extract - 250 mg
coq10 for more energy
vinpocetine for
brain function support
sarsaparilla
herb