Scleroderma is a chronic, degenerative, autoimmune disease that leads to the over-production of collagen in the body's connective tissue. The word "scleroderma" means "hardening of the skin" and refers to one of the possible physical effects of the disease. If systemic (throughout the body), scleroderma is known as progressive systemic sclerosis. Scleroderma has been described in South African gold miners, where it is thought to be related to silica dust exposure. Scleroderma has also been found in jewelry workers and miners who worked with quartz. People who live near airports having a higher incidence of Scleroderma.
Natural Scleroderma
Treatment
Hardly any research is available regarding the treatment of
scleroderma with natural herbs and nutrients. However, some lab studies
are beginning to be done regarding the benefit of herbal extracts. One
such herb being evaluated is
curcumin. Little is
known whether taking a curcumin supplement would have an influence on the
actual clinical picture of scleroderma.
Pol Merkur Lekarski. 2013. Increased level of lipid peroxidation products and disturbances in oxidation-reduction balance in erythrocytes from patients suffering from systemic sclerosis, who are chronically treated with vitamin E. In view of the reports of essential role of oxidative stress in development of disease, trials with supportive care with vitamin E are undertaken. The aim of the study was to estimate parameters of oxidation-reduction balance in erythrocytes from scleroderma patients, who were chronically treated with vitamin E compared with healthy controls. In scleroderma patients despite chronical treatment with vitamin E, oxidation-reduction balance disturbances are observed in the form of increased level of lipid peroxidation products. Besides, a lower activity of catalase and superoxide dysmutase in patients who suffer from diffuse form of systemic sclerosis is noted. Patients with limited systemic sclerosis have higher glutathione peroxidase activity.
Scleroderma symptom and
sign
The first warning signs of scleroderma usually involve the skin.
Hard round or oval patches may appear on your skin. These patches are
usually white with a reddish area around them. They may appear on your
chest, stomach, face, arms, legs or other parts of the body. If you have
generalized scleroderma a larger area of skin will be affected. You may
also have other warning signs. Small white chalky lumps may form under
your skin. These lumps usually form around the fingers but can occur
anywhere in the body. If these break through your skin a chalky white
material might ooze out. Your fingers and toes may turn blue and become
numb and painful when you are cold or upset. You could have trouble
swallowing or get heartburn.
Scleroderma treatment
Systemic sclerosis is a disease whose treatment is focused at
pathogenic pathways causing variable types of damage in the individual
organs. There are 3 major pathways that cause organ damage in scleroderma.
First, t-cells, cytokines and inflammation are prominent very early in the
disease. Early alveolitis which occurs before interestial fibrosis in the
lungs is the best example of inflammation. Second, endothelial cell damage
causes severe thickening of vessels and two of the most deadly
complications in scleroderma, pulmonary arterial hypertension and renal
crisis. Scleroderma renal crisis is now very treatable with angiotensin
converting enzyme inhibitors. There are now treatments for pulmonary
arterial hypertension which should improve outcome in these patients as
well. Third, fibroblasts lead to severe cutaneous fibrosis or skin
thickening that is the hallmark of the disease. No treatment is available
but new antagonists to the cytokine, TGF beta, may prove helpful.
Localized Scleroderma
Treatment
Phototherapy is an effective therapeutic option in localized scleroderma,
Phototherapy should be considered among the first approaches in the
management of localized scleroderma. Morphea scleroderma.
Finger Workout for
Scleroderma
Finger-stretching exercises can improve range of motion in the joints. Dr. Minoru Hasegawa, of Kanazawa
University Graduate School of Medical Science, Ishikawa, Japan, and
colleagues assessed the efficacy of self-administered stretching of each
finger in 32 patients with diffuse cutaneous systemic sclerosis and 13
with limited cutaneous systemic sclerosis. The patients received
instruction on finger stretching exercises and were asked to perform them
daily. Each finger was maintained in a stretched position using the
opposite hand for 10 seconds; this was repeated 3 to 10 times. After 1
month of finger stretching, the total passive range of motion was
significantly improved and was maintained or further improved at 1 year.
Patients with diffuse cutaneous systemic sclerosis had less range of
motion than those with limited cutaneous systemic sclerosis. However,
there was a significant increase in range of motion regardless of disease
duration or severity of skin sclerosis. Journal of Rheumatology 2006.
Promising results are emerging from targeting cytokine signaling, including IL-6, and from other immune-inflammatory therapies including lipid mediators such as LPA1.
Scleroderma Research
studies
Curcumin -induced apoptosis in scleroderma lung fibroblasts: role
of protein kinase cepsilon.
Am J Respir Cell Mol Biol. 2004. Tourkina E, Gooz P, Oates JC, Ludwicka-Bradley
A, Hoffman S.
Department of Medicine, Medical University of South Carolina, Charleston,
SC, USA.
Scleroderma, a disease involving excessive collagen deposition, can be
studied using fibroblasts cultured from affected tissues. We find that
curcumin, the active component of the spice turmeric, causes apoptosis in
scleroderma lung fibroblasts (SLF), but not in normal lung fibroblasts (NLF).
This effect is likely to be linked to the fact that although curcumin
induces the expression of the phase 2 detoxification enzymes heme
oxygenase 1 and glutathione S-transferase P1 (GST P1) in NLF, SLF are
deficient in these enzymes, particularly after curcumin treatment. In
summary, our results suggest that a signaling pathway involving PKCepsilon
and phase 2 detoxification enzymes provides protection against curcumin-induced
apoptosis in NLF and is defective in SLF. These observations suggest that
curcumin may have therapeutic value in treating scleroderma, just as it
has already been shown to protect rats from lung fibrosis induced by a
variety of agents.
Autoimmun Rev. 2016. Genetic factors and systemic sclerosis. Systemic sclerosis (SSc) is a rare connective tissue disease of unknown etiology characterized by chronic inflammation and fibrosis of the skin, vascular abnormalities, and variable involvement of organs including kidneys, gastrointestinal tract, heart, and lungs. SSc shows a complex etiology in which both environmental and genetic factors seem to influence the onset and outcome of the disease.
Scleroderma natural
treatment questions and testimonials
Is there a natural product that would be useful for treating my wife
who has scleroderma. I am a physician and have tried all of the
traditional treatments and have had no success. We are currently in the
process of having her dental work redone to remove any mercury containing
fillings removed. I am open to any suggestions.
We have not much research with scleroderma and natural herbs or
supplements. Perhaps turmeric or curcumin could be one option.
I have Scleroderma, and it effects the outside of
the body, especiallly the hand, it is stiff and I can't open my fingers out,
they are permanately in a position like i'm holding a snooker ball, can you
suggest anything that might help?
At this time we are not aware of any effective natural treatment
for scleroderma that has been tested in humans.
I’m trying to learn more about what Dr. Shelian’s website would say, if anything, with regard to supplements that might or may be used for supporting one who may have scleroderma. Any references or thoughts on this ailment would be of interest to me. A I’ve passed on your valuable website to many and we all read it!
My sister was diagnosed with scleroderma. What advice can you give such as the best known medical treatment and/or natural supplements or herbs that can help? Would a homeopathic or Naturopathic Doctor help with slowing down the process? Do you know of any one who has been cured or able to reverse the scar tissue breakdown? Please help.
I wonder if you might be interested in the true story of my successful self treatment of scleroderma by my having implemented a very simple vitamin regimen. All the scleroderma forums I looked at seemed to have adamantly ruled out advocating any particular vitamin therapy with regard to scleroderma, even though that is one pretty obvious possible avenue of exploration. One year after I had raised my intake of niacin amide to 800 mg per day, an inflammation and thickening of the skin, plus 10 ulcers, some of them quite large, developed on the lower halves of both my lower legs. Three years later, while I was fasting for a laboratory blood test, the ulcers appeared to get noticeably better in just that short fasting period. I therefore lowered my daily intake of niacin amide to 50 mg per day. By two years later all the ulcers had gone; and no further expansion of the sclerosed tissue has taken place. It seems to me that my unfortunate experience with high niacinamide use should be a pretty useful clue to the cause of at least one type of systemic scleroderma. I also take 50 mg of nicotinic acid per day just in case that prevents Raynaud's disease, which I used to have a mild version of, and which I theorize could happen if the nicotinic acid gets crowded out of the system by the presence of too much niacin amide.
I wonder if you might be interested in the true story of my successful self treatment of scleroderma by my having implemented a very simple vitamin regimen. All the scleroderma forums I looked at seemed to have adamantly ruled out advocating any particular vitamin therapy, even though that is one pretty obvious possible avenue of exploration. One year after I had raised my intake of niacin amide to 800mg per day, an inflammation and thickening of the skin, plus 10 ulcers, some of them quite large, developed on the lower halves of both my lower legs. Three years later, while I was fasting for a laboratory blood test, the ulcers appeared to get noticeably better in just that short fasting period. I therefore lowered my daily intake of niacin amide to 50 mg per day. By two years later all the ulcers had gone; and no further expansion of the sclerosed tissue has taken place. It seems to me that my unfortunate experience with high niacin amide use should be a pretty useful clue to the cause of at least one type of systemic scleroderma.
My niece who is 21 years old has been diagnosed with scleroderma. I would really appreciate it if you can suggest some alternative therapy. She is getting treated with Viagra and Mycophenolic acid tablets. Symptoms like thickening of the skin, lips getting smaller, joint pain all occurring at the moment.
My mother has scleroderma. Though she has tried traditional treatments for this autoimmune disorder -- like a stem cell transplant at MD Anderson) -- unfortunately, she has not seen any positive outcomes. Now 3 years later, she is looking to try alternative treatments.
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