Uridine benefit and review and natural medicine information by Ray Sahelian, M.D.
April 10 2016


Cytidine and uridine can stimulate brain phosphatide synthesis. MIT brain researchers are working on a combination of dietary supplements that may be helpful in mind enhancement or the treatment of age related mental decline. The MIT research suggests that a cocktail treatment of omega-3 fatty acids, uridine and choline are all needed by brain neurons to make phospholipids, the primary component of cell membranes. After adding those supplements to the diets of gerbils, the researchers observed a dramatic increase in the amount of membranes that form brain cell synapses, where messages between cells are relayed. Damage in brain synapses is believed to cause the dementia that characterizes Alzheimer's disease. Mind Power Rx is a formula for better mental focus and concentration.


Definition of Uridine - a molecule known as a nucleoside formed when uracil is attached to a ribose ring. If uracil is attached to a deoxyribose ring, it is known as a deoxyuridine.


Liver role
PLoS One. Jan 24 2014. Uridine prevents fenofibrate-induced Fatty liver. Uridine, a pyrimidine nucleoside, can modulate liver lipid metabolism although its specific acting targets have not been identified. Using mice with fenofibrate-induced fatty liver as a model system, the effects of uridine on liver lipid metabolism are examined. At a daily dosage of 400 mg/kg, fenofibrate treatment causes reduction of liver NAD(+)/NADH ratio, induces hyper-acetylation of peroxisomal bifunctional enzyme (ECHD) and acyl-CoA oxidase 1 (ACOX1), and induces excessive accumulation of long chain fatty acids (LCFA) and very long chain fatty acids (VLCFA). Uridine co-administration at a daily dosage of 400 mg/kg raises NAD(+)/NADH ratio, inhibits fenofibrate-induced hyper-acetylation of ECHD, ACOX1, and reduces accumulation of LCFA and VLCFA. Our data indicates a therapeutic potential for uridine co-administration to prevent fenofibrate-induced fatty liver.


Uridine Research
Neural Plast. 2016. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice. APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer's disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD.


Cytidine and Uridine Increase Striatal CDP-Choline Levels Without Decreasing Acetylcholine Synthesis or Release.
Cell Mol Neurobiol. 2006.
Department of Pharmacology and Clinical Pharmacology, Uludag University Medical School, Bursa, Turkey.

Treatments that increase acetylcholine release from brain slices decrease the synthesis of phosphatidylcholine by, and its levels in, the slices. We examined whether adding cytidine or uridine to the slice medium, which increases the utilization of choline to form phospholipids, also decreases acetylcholine levels and release. These data show that cytidine and uridine can stimulate brain phosphatide synthesis without diminishing acetylcholine synthesis or release.


Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally.
Brain Res. 2006; Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G.
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, MIT, Cambridge, MA
The synthesis of brain phosphatidylcholine may utilize three circulating precursors: choline; a pyrimidine (e.g., uridine, converted via UTP to brain CTP); and a PUFA (e.g., docosahexaenoic acid); phosphatidylethanolamine may utilize two of these, a pyrimidine and a PUFA. We observe that consuming these precursors can substantially increase membrane phosphatide and synaptic protein levels in gerbil brains. Alzheimer's disease brains contain fewer and smaller synapses and reduced levels of synaptic proteins, membrane phosphatides, choline and DHA. The three phosphatide precursors might thus be useful in treating this disease.


Effects of uridine in models of epileptogenesis and seizures.
Epilepsy Res. 2006; Zhao Q, Marolewski A, Rusche JR, Holmes GL.
Neuroscience Center at Dartmouth, Section of Neurology, Dartmouth Medical School, Lebanon, New Hampshire
Uridine, a possible endogenous antiepileptic modulator, has been demonstrated to have anticonvulsant effects in some models of epilepsy. In this study, we examined possible neuroprotective effects of uridine by administering the agent following lithium-pilocarpine induced status epilepticus.  There was a trend for reduced EEG spike frequency, improved visual spatial memory and better histology score in rats receiving uridine. The antiepileptogenic and anticonvulsant effects of uridine were studied by administering uridine to rats undergoing rapid kindling or following full kindling. In the rapid kindling models, uridine had a moderate antiepileptogenic and anticonvulsant effect. These results suggest uridine may have potential to aid in the prevention and treatment of epilepsy.


Q. I am looking for a daily rridine treatment for a patient (20 mo old female with hereditary Orotic aciduria) , and having difficulties finding a supplier. Your web site comes up as a source for information. I would appreciate if you can let me know of a pharmaceutical grade supplier for Uridine.
   A. Sorry, we have not looked into sales of uridine or suppliers.


Q. I'm just wondering uridine is not found in Mind Power Rx formula.
   A. There are dozens of effective mind boosting herbs and nutrients. Mind Power Rx has about a dozen of them. Not every potential mind enhancer can be included in a formula.


I am a pharmacist at the Medical University of South Carolina. I am working with a physician to try and locate a product called Uridin Uridine. We have a patient who has been on this chronically since childhood for Hereditary Orotic Aciduria. The patient can no longer find this supplement and has tried to locate something similar at numerous pharmacies with no luck. They are saying this product has been discontinued but I cannot even find any information on the discontinuation of such product. Please contact us if you have any knowledge of a supplement that contains uridine for human consumption. We are in need of this product as soon as possible.
    If you do a google search there appears to be some companies that sell Uridine Triacetyluridine 25mg. I am not familiar with Uridin product.